Drug interactions
Mesterolone + Simvastatin
Severity: Minor
Mesterolone and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesterolone is an androgen with no established CYP3A4 inhibition, and the claimed interaction is extrapolated from danazol, which does inhibit CYP3A4. There is no good evidence of a meaningful effect on simvastatin.
What this interaction means in plain words
Mesterolone and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesterolone belongs to Endocrine; Simvastatin belongs to Cardiovascular.
Why it happens
No established mechanism; the interaction is theoretical and extrapolated from danazol.
What to do
No specific action is required. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Mesterolone
Frequently asked questions
Can I take Mesterolone with Simvastatin?
MediHelp rates the interaction as minor. Mesterolone and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesterolone is an androgen with no established CYP3A4 inhibition, and the claimed interaction is extrapolated from danazol, which does inhibit CYP3A4. There is no good evidence of a meaningful effect on simvastatin.
How serious is the interaction between Mesterolone and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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