Drug interactions
Mesterolone + Tolbutamide
Severity: Minor
Mesterolone and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens can improve insulin sensitivity and lower glucose, which may potentiate tolbutamide and lead to hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Mesterolone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesterolone belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Androgen-related improvement in insulin sensitivity adds to sulfonylurea glucose lowering.
What to do
Monitor blood glucose when mesterolone is started or stopped and reduce tolbutamide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Mesterolone
Frequently asked questions
Can I take Mesterolone with Tolbutamide?
MediHelp rates the interaction as minor. Mesterolone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgens can improve insulin sensitivity and lower glucose, which may potentiate tolbutamide and lead to hypoglycemia. The effect is usually modest.
How serious is the interaction between Mesterolone and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when mesterolone is started or stopped and reduce tolbutamide if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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