Drug interactions
Mestranol + Posaconazole
Severity: Minor
Mestranol and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase estrogen exposure from mestranol, which is converted to ethinylestradiol. This could increase estrogenic adverse effects such as nausea, breast tenderness and thromboembolic risk.
What this interaction means in plain words
Mestranol and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4, reducing metabolism of mestranol and ethinylestradiol.
What to do
No routine adjustment is needed. Monitor for estrogenic adverse effects and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Mestranol with Posaconazole?
MediHelp rates the interaction as minor. Mestranol and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase estrogen exposure from mestranol, which is converted to ethinylestradiol. This could increase estrogenic adverse effects such as nausea, breast tenderness and thromboembolic risk.
How serious is the interaction between Mestranol and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for estrogenic adverse effects and blood pressure.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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