Drug interactions
Mestranol + Tigecycline
Severity: Minor
Mestranol and Tigecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorised to lower estrogen levels by disrupting gut bacteria that help recycle estrogens. Clinical evidence is lacking, and the risk of contraceptive failure with mestranol is thought to be low.
What this interaction means in plain words
Mestranol and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogens through altered intestinal flora.
What to do
Consider advising a backup barrier method during tigecycline therapy. No dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tigecycline
Frequently asked questions
Can I take Mestranol with Tigecycline?
MediHelp rates the interaction as minor. Mestranol and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorised to lower estrogen levels by disrupting gut bacteria that help recycle estrogens. Clinical evidence is lacking, and the risk of contraceptive failure with mestranol is thought to be low.
How serious is the interaction between Mestranol and Tigecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider advising a backup barrier method during tigecycline therapy. No dose change is required.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
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