Drug interactions
Metaxalone + Midazolam
Severity: Major
Metaxalone and Midazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent benzodiazepine sedative, and metaxalone may add to its central depressant effect. This increases the chance of deep sedation, impaired airway control and respiratory depression, particularly during procedures.
What this interaction means in plain words
Metaxalone and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metaxalone belongs to Musculoskeletal; Midazolam belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Titrate midazolam cautiously with reduced initial doses in patients taking metaxalone, and monitor oxygen saturation and respiration continuously. Ensure airway support is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metaxalone
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Metaxalone with Midazolam?
MediHelp rates the interaction as major. Metaxalone and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midazolam is a potent benzodiazepine sedative, and metaxalone may add to its central depressant effect. This increases the chance of deep sedation, impaired airway control and respiratory depression, particularly during procedures.
How serious is the interaction between Metaxalone and Midazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam cautiously with reduced initial doses in patients taking metaxalone, and monitor oxygen saturation and respiration continuously. Ensure airway support is available.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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