Drug interactions
Metaxalone + Mirabegron
Severity: Minor
Metaxalone and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is metabolised mainly by CYP1A2 with minor contributions from CYP2D6 and others. A clinically meaningful interaction with mirabegron is not established.
What this interaction means in plain words
Metaxalone and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron weakly inhibits CYP2D6, a minor pathway for metaxalone.
What to do
No action is generally required; watch for increased drowsiness or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Mirabegron?
MediHelp rates the interaction as minor. Metaxalone and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metaxalone is metabolised mainly by CYP1A2 with minor contributions from CYP2D6 and others. A clinically meaningful interaction with mirabegron is not established.
How serious is the interaction between Metaxalone and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; watch for increased drowsiness or dizziness.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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