Drug interactions
Metaxalone + Ribociclib
Severity: Moderate
Metaxalone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor, and metaxalone is partly metabolized by CYP3A4 among other enzymes. Metaxalone exposure may rise, increasing drowsiness, dizziness and other adverse effects.
What this interaction means in plain words
Metaxalone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing metabolism of metaxalone.
What to do
Monitor for excess sedation and dizziness, and consider a lower metaxalone dose or an alternative muscle relaxant during ribociclib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Metaxalone with Ribociclib?
MediHelp rates the interaction as moderate. Metaxalone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate to strong CYP3A4 inhibitor, and metaxalone is partly metabolized by CYP3A4 among other enzymes. Metaxalone exposure may rise, increasing drowsiness, dizziness and other adverse effects.
How serious is the interaction between Metaxalone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, and consider a lower metaxalone dose or an alternative muscle relaxant during ribociclib therapy.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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