Drug interactions
Metaxalone + Tecovirimat
Severity: Minor
Metaxalone and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly reduce metaxalone exposure. The effect is likely small and short-lived given the usual 14-day tecovirimat course.
What this interaction means in plain words
Metaxalone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases metaxalone clearance.
What to do
Monitor for reduced muscle relaxant effect during tecovirimat therapy and adjust the metaxalone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Metaxalone with Tecovirimat?
MediHelp rates the interaction as minor. Metaxalone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly reduce metaxalone exposure. The effect is likely small and short-lived given the usual 14-day tecovirimat course.
How serious is the interaction between Metaxalone and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced muscle relaxant effect during tecovirimat therapy and adjust the metaxalone dose if needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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