Drug interactions
Metaxalone + Ziconotide
Severity: Moderate
Metaxalone and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, commonly causes dizziness, sedation and cognitive impairment, which metaxalone may worsen. Depressed consciousness can be serious and may require stopping ziconotide.
What this interaction means in plain words
Metaxalone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression and cognitive impairment.
What to do
Monitor mental status and level of alertness, and reduce or stop the sedating agent if impairment develops. Avoid adding other CNS depressants unnecessarily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Metaxalone with Ziconotide?
MediHelp rates the interaction as moderate. Metaxalone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, given intrathecally, commonly causes dizziness, sedation and cognitive impairment, which metaxalone may worsen. Depressed consciousness can be serious and may require stopping ziconotide.
How serious is the interaction between Metaxalone and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of alertness, and reduce or stop the sedating agent if impairment develops. Avoid adding other CNS depressants unnecessarily.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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