Drug interactions
Metformin + Pacritinib
Severity: Moderate
Metformin and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib may inhibit hepatic uptake of metformin, raising its systemic concentrations. This could increase glucose-lowering and the risk of gastrointestinal effects or, rarely, lactic acidosis.
What this interaction means in plain words
Metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Pacritinib belongs to Oncology.
Why it happens
Pacritinib inhibits OCT1, reducing hepatic uptake of metformin.
What to do
Monitor glucose and renal function and watch for gastrointestinal intolerance or lactic acidosis symptoms. Reduce the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Metformin with Pacritinib?
MediHelp rates the interaction as moderate. Metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib may inhibit hepatic uptake of metformin, raising its systemic concentrations. This could increase glucose-lowering and the risk of gastrointestinal effects or, rarely, lactic acidosis.
How serious is the interaction between Metformin and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function and watch for gastrointestinal intolerance or lactic acidosis symptoms. Reduce the metformin dose if adverse effects appear.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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