Drug interactions
Metformin + Prochlorperazine
Severity: Moderate
Metformin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can cause hyperglycemia and may weaken glycemic control in patients taking metformin. Glucose may fall again when the phenothiazine is stopped.
What this interaction means in plain words
Metformin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as phenothiazines may impair insulin secretion and promote insulin resistance.
What to do
Monitor blood glucose when starting or stopping prochlorperazine and adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Prochlorperazine?
MediHelp rates the interaction as moderate. Metformin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can cause hyperglycemia and may weaken glycemic control in patients taking metformin. Glucose may fall again when the phenothiazine is stopped.
How serious is the interaction between Metformin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping prochlorperazine and adjust the antidiabetic regimen if needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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