Drug interactions
Metformin + Progesterone
Severity: Minor
Metformin and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens can modestly impair glucose tolerance and may slightly reduce the glucose-lowering effect of metformin. The effect with natural progesterone is generally small.
What this interaction means in plain words
Metformin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through progestogen-related reduction in insulin sensitivity.
What to do
Monitor blood glucose or HbA1c when progesterone is started or stopped, and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Progesterone?
MediHelp rates the interaction as minor. Metformin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens can modestly impair glucose tolerance and may slightly reduce the glucose-lowering effect of metformin. The effect with natural progesterone is generally small.
How serious is the interaction between Metformin and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose or HbA1c when progesterone is started or stopped, and adjust antidiabetic therapy if control changes.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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