Drug interactions
Metformin + Tibolone
Severity: Minor
Metformin and Tibolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tibolone has weak estrogenic, progestogenic and androgenic effects, and its influence on glucose tolerance is small and inconsistent. A clinically meaningful loss of metformin effect is not well established.
What this interaction means in plain words
Metformin and Tibolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Tibolone belongs to Endocrine.
Why it happens
Possible minor effect on insulin sensitivity; no established mechanism.
What to do
No routine action beyond usual glucose monitoring when starting or stopping tibolone in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Tibolone
- Amobarbital + Tibolone Moderate
- Carbamazepine + Tibolone Moderate
- Secobarbital + Tibolone Moderate
- Alogliptin-metformin + Tibolone Minor
- Argatroban + Tibolone Minor
- Dapagliflozin-metformin + Tibolone Minor
Frequently asked questions
Can I take Metformin with Tibolone?
MediHelp rates the interaction as minor. Metformin and Tibolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tibolone has weak estrogenic, progestogenic and androgenic effects, and its influence on glucose tolerance is small and inconsistent. A clinically meaningful loss of metformin effect is not well established.
How serious is the interaction between Metformin and Tibolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action beyond usual glucose monitoring when starting or stopping tibolone in diabetic patients.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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