Drug interactions
Metformin-pioglitazone + Midodrine
Severity: Minor
Metformin-pioglitazone and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and midodrine's active metabolite are both eliminated by renal tubular secretion, so competition could modestly raise levels of either. The clinical significance is thought to be small.
What this interaction means in plain words
Metformin-pioglitazone and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Midodrine belongs to Miscellaneous.
Why it happens
Possible competition for renal tubular cationic transport reduces clearance.
What to do
No routine adjustment is needed; monitor blood pressure and renal function in patients with impaired kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Metformin-pioglitazone with Midodrine?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin and midodrine's active metabolite are both eliminated by renal tubular secretion, so competition could modestly raise levels of either. The clinical significance is thought to be small.
How serious is the interaction between Metformin-pioglitazone and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and renal function in patients with impaired kidney function.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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