Drug interactions
Metformin-pioglitazone + Nevirapine
Severity: Minor
Metformin-pioglitazone and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may modestly lower pioglitazone exposure, since pioglitazone is metabolized mainly by CYP2C8 with some CYP3A4 contribution. The effect on glycemic control is expected to be small but could reduce efficacy in some patients.
What this interaction means in plain words
Metformin-pioglitazone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induction of CYP3A4 (and possibly CYP2C8) increases pioglitazone metabolism.
What to do
No empirical dose change is needed; check glucose and HbA1c after starting or stopping nevirapine and adjust the pioglitazone dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Metformin-pioglitazone with Nevirapine?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4 and may modestly lower pioglitazone exposure, since pioglitazone is metabolized mainly by CYP2C8 with some CYP3A4 contribution. The effect on glycemic control is expected to be small but could reduce efficacy in some patients.
How serious is the interaction between Metformin-pioglitazone and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; check glucose and HbA1c after starting or stopping nevirapine and adjust the pioglitazone dose if control changes.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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