Drug interactions
Metformin-pioglitazone + Omaveloxolone
Severity: Moderate
Metformin-pioglitazone and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may lower the systemic exposure of drugs that depend on CYP2C8 for clearance, and pioglitazone is a CYP2C8 substrate. Reduced pioglitazone exposure could blunt glycemic control.
What this interaction means in plain words
Metformin-pioglitazone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Omaveloxolone is thought to induce CYP2C8, which increases the metabolism of pioglitazone.
What to do
Monitor blood glucose and HbA1c after omaveloxolone is started or stopped. Increase the pioglitazone dose if glycemic control worsens, within the maximum labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Metformin-pioglitazone with Omaveloxolone?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may lower the systemic exposure of drugs that depend on CYP2C8 for clearance, and pioglitazone is a CYP2C8 substrate. Reduced pioglitazone exposure could blunt glycemic control.
How serious is the interaction between Metformin-pioglitazone and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after omaveloxolone is started or stopped. Increase the pioglitazone dose if glycemic control worsens, within the maximum labeled dose.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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