Drug interactions
Metformin-pioglitazone + Temsirolimus
Severity: Moderate
Metformin-pioglitazone and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus frequently causes hyperglycemia and hyperlipidemia, which may reduce the glycemic control provided by metformin and pioglitazone. Antidiabetic doses often need to be increased.
What this interaction means in plain words
Metformin-pioglitazone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
Pharmacodynamic antagonism via mTOR inhibition-related insulin resistance.
What to do
Monitor blood glucose regularly during therapy and titrate antidiabetic drugs accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Temsirolimus?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus frequently causes hyperglycemia and hyperlipidemia, which may reduce the glycemic control provided by metformin and pioglitazone. Antidiabetic doses often need to be increased.
How serious is the interaction between Metformin-pioglitazone and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during therapy and titrate antidiabetic drugs accordingly.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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