Drug interactions
Metformin-pioglitazone + Vadadustat
Severity: Minor
Metformin-pioglitazone and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs that inhibit OAT1/OAT3 may increase vadadustat exposure, which could lead to an excessive rise in hemoglobin and more adverse effects such as thrombosis or hypertension. Pioglitazone is not a well-established inhibitor of these transporters, so the effect is largely predicted.
What this interaction means in plain words
Metformin-pioglitazone and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3 renal and hepatic uptake of vadadustat, reducing its clearance.
What to do
Monitor hemoglobin regularly during vadadustat therapy and adjust the dose according to the response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Metformin-pioglitazone with Vadadustat?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs that inhibit OAT1/OAT3 may increase vadadustat exposure, which could lead to an excessive rise in hemoglobin and more adverse effects such as thrombosis or hypertension. Pioglitazone is not a well-established inhibitor of these transporters, so the effect is largely predicted.
How serious is the interaction between Metformin-pioglitazone and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly during vadadustat therapy and adjust the dose according to the response.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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