Drug interactions
Metformin-repaglinide + Methylprednisolone
Severity: Moderate
Metformin-repaglinide and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as methylprednisolone raise blood glucose and can substantially reduce antidiabetic control. Glucose-lowering requirements often rise during steroid therapy and fall after withdrawal.
What this interaction means in plain words
Metformin-repaglinide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Methylprednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, pharmacodynamically opposing antidiabetic drugs.
What to do
Monitor blood glucose during steroid therapy and increase antidiabetic therapy as required, reducing doses again when steroids are tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Methylprednisolone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as methylprednisolone raise blood glucose and can substantially reduce antidiabetic control. Glucose-lowering requirements often rise during steroid therapy and fall after withdrawal.
How serious is the interaction between Metformin-repaglinide and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during steroid therapy and increase antidiabetic therapy as required, reducing doses again when steroids are tapered.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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