Drug interactions
Metformin-repaglinide + Metolazone
Severity: Moderate
Metformin-repaglinide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a thiazide-like diuretic that can raise blood glucose and so reduce the effectiveness of metformin and repaglinide. Fluid loss and electrolyte disturbances may add to this effect.
What this interaction means in plain words
Metformin-repaglinide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and reduced insulin sensitivity antagonize antidiabetic drug action.
What to do
Monitor blood glucose, potassium and renal function after starting or changing metolazone, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Metolazone
Frequently asked questions
Can I take Metformin-repaglinide with Metolazone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone is a thiazide-like diuretic that can raise blood glucose and so reduce the effectiveness of metformin and repaglinide. Fluid loss and electrolyte disturbances may add to this effect.
How serious is the interaction between Metformin-repaglinide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function after starting or changing metolazone, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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