Drug interactions
Metformin-repaglinide + Midodrine
Severity: Minor
Metformin-repaglinide and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin is a substrate of renal cationic transporters and midodrine's active metabolite is also secreted by this pathway, so competition is theoretically possible. No clinically meaningful effect has been established.
What this interaction means in plain words
Metformin-repaglinide and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Midodrine belongs to Miscellaneous.
Why it happens
Theoretical competition for renal tubular cationic secretion.
What to do
No routine action is needed. Monitor renal function and clinical response in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Metformin-repaglinide with Midodrine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin is a substrate of renal cationic transporters and midodrine's active metabolite is also secreted by this pathway, so competition is theoretically possible. No clinically meaningful effect has been established.
How serious is the interaction between Metformin-repaglinide and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor renal function and clinical response in patients with renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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