Drug interactions
Metformin-repaglinide + Nevirapine
Severity: Moderate
Metformin-repaglinide and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces hepatic enzymes and may lower repaglinide exposure, reducing its glucose-lowering effect. Glycemic control may deteriorate after nevirapine is started.
What this interaction means in plain words
Metformin-repaglinide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 (and possibly CYP2C8), accelerating repaglinide metabolism.
What to do
Monitor blood glucose after starting or stopping nevirapine and titrate the repaglinide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Metformin-repaglinide with Nevirapine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces hepatic enzymes and may lower repaglinide exposure, reducing its glucose-lowering effect. Glycemic control may deteriorate after nevirapine is started.
How serious is the interaction between Metformin-repaglinide and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping nevirapine and titrate the repaglinide dose as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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