Drug interactions
Metformin-repaglinide + Omaveloxolone
Severity: Moderate
Metformin-repaglinide and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and CYP2C8, both of which metabolize repaglinide, and could lower repaglinide exposure. This may lead to reduced glycemic control.
What this interaction means in plain words
Metformin-repaglinide and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and CYP2C8 increases repaglinide metabolism.
What to do
Monitor blood glucose after starting omaveloxolone and increase the repaglinide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Metformin-repaglinide with Omaveloxolone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP3A4 and CYP2C8, both of which metabolize repaglinide, and could lower repaglinide exposure. This may lead to reduced glycemic control.
How serious is the interaction between Metformin-repaglinide and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting omaveloxolone and increase the repaglinide dose if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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