Drug interactions
Metformin-repaglinide + Ondansetron
Severity: Minor
Metformin-repaglinide and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron may reduce renal secretion of metformin, modestly increasing its plasma concentrations. The clinical consequence is generally small, though higher metformin exposure matters in renal impairment.
What this interaction means in plain words
Metformin-repaglinide and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Ondansetron may inhibit renal tubular transporters (OCT2/MATE) involved in metformin secretion.
What to do
No routine adjustment needed; monitor renal function and glycemic control in patients with renal impairment on long-term combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Metformin-repaglinide with Ondansetron?
MediHelp rates the interaction as minor. Metformin-repaglinide and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron may reduce renal secretion of metformin, modestly increasing its plasma concentrations. The clinical consequence is generally small, though higher metformin exposure matters in renal impairment.
How serious is the interaction between Metformin-repaglinide and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor renal function and glycemic control in patients with renal impairment on long-term combined therapy.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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