Drug interactions
Metformin-repaglinide + Pegvisomant
Severity: Moderate
Metformin-repaglinide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, which can improve insulin sensitivity and lower glucose. In diabetic patients on antidiabetic drugs this may lead to hypoglycemia.
What this interaction means in plain words
Metformin-repaglinide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance, adding to the glucose-lowering effect.
What to do
Monitor blood glucose when starting pegvisomant and reduce the dose of repaglinide or other antidiabetic drugs if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Pegvisomant?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action, which can improve insulin sensitivity and lower glucose. In diabetic patients on antidiabetic drugs this may lead to hypoglycemia.
How serious is the interaction between Metformin-repaglinide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting pegvisomant and reduce the dose of repaglinide or other antidiabetic drugs if glucose falls.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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