Drug interactions
Metformin-repaglinide + Repotrectinib
Severity: Moderate
Metformin-repaglinide and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may lower repaglinide concentrations, reducing glycemic control.
What this interaction means in plain words
Metformin-repaglinide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction increases repaglinide metabolism.
What to do
Monitor blood glucose and adjust the repaglinide dose, or switch to another antidiabetic agent if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Metformin-repaglinide with Repotrectinib?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and may lower repaglinide concentrations, reducing glycemic control.
How serious is the interaction between Metformin-repaglinide and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the repaglinide dose, or switch to another antidiabetic agent if control is lost.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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