Drug interactions
Metformin-repaglinide + Risperidone
Severity: Moderate
Metformin-repaglinide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone and other atypical antipsychotics can cause hyperglycemia and impair glycemic control, opposing the effects of metformin and repaglinide. Patients with diabetes may need more intensive treatment.
What this interaction means in plain words
Metformin-repaglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and impaired insulin secretion oppose antidiabetic action (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c after starting or changing risperidone. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Metformin-repaglinide with Risperidone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone and other atypical antipsychotics can cause hyperglycemia and impair glycemic control, opposing the effects of metformin and repaglinide. Patients with diabetes may need more intensive treatment.
How serious is the interaction between Metformin-repaglinide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing risperidone. Adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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