Drug interactions
Metformin-repaglinide + Stiripentol
Severity: Moderate
Metformin-repaglinide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C8 and CYP3A4 and can also induce some CYP enzymes, so repaglinide exposure may change. Increased exposure could cause hypoglycemia.
What this interaction means in plain words
Metformin-repaglinide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C8 and CYP3A4, key pathways of repaglinide metabolism, though it can also induce CYP3A4.
What to do
Monitor blood glucose when stiripentol is started or stopped. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Stiripentol
Frequently asked questions
Can I take Metformin-repaglinide with Stiripentol?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C8 and CYP3A4 and can also induce some CYP enzymes, so repaglinide exposure may change. Increased exposure could cause hypoglycemia.
How serious is the interaction between Metformin-repaglinide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when stiripentol is started or stopped. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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