Drug interactions
Metformin-repaglinide + Trimipramine
Severity: Minor
Metformin-repaglinide and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may occasionally alter glycemic control and have been linked to hypoglycemia in patients using antidiabetic drugs. The effect is inconsistent and generally minor.
What this interaction means in plain words
Metformin-repaglinide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not well established.
What to do
Monitor blood glucose when trimipramine is started or stopped and adjust the antidiabetic regimen only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Trimipramine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may occasionally alter glycemic control and have been linked to hypoglycemia in patients using antidiabetic drugs. The effect is inconsistent and generally minor.
How serious is the interaction between Metformin-repaglinide and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trimipramine is started or stopped and adjust the antidiabetic regimen only if control changes.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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