Drug interactions
Metformin-repaglinide + Vortioxetine
Severity: Minor
Metformin-repaglinide and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants such as vortioxetine may modestly alter glucose homeostasis, and hypoglycemia has occasionally been reported when they are added to antidiabetic therapy. The effect is generally small and unpredictable.
What this interaction means in plain words
Metformin-repaglinide and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Vortioxetine belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; the mechanism is not firmly established.
What to do
Advise patients to monitor blood glucose when vortioxetine is started or stopped and adjust the antidiabetic regimen only if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Vortioxetine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants such as vortioxetine may modestly alter glucose homeostasis, and hypoglycemia has occasionally been reported when they are added to antidiabetic therapy. The effect is generally small and unpredictable.
How serious is the interaction between Metformin-repaglinide and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose when vortioxetine is started or stopped and adjust the antidiabetic regimen only if glucose changes.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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