Drug interactions
Metformin-sitagliptin + Prochlorperazine
Severity: Moderate
Metformin-sitagliptin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine can raise blood glucose and impair glycemic control in patients with diabetes. This may reduce the effectiveness of metformin-sitagliptin, and glucose may fall again when the phenothiazine is stopped.
What this interaction means in plain words
Metformin-sitagliptin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazines can impair insulin secretion and cause insulin resistance, producing a pharmacodynamic opposition to antidiabetic effect.
What to do
Monitor blood glucose when prochlorperazine is started, changed or stopped, and adjust antidiabetic therapy if needed. Short antiemetic courses rarely need intervention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Metformin-sitagliptin with Prochlorperazine?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as prochlorperazine can raise blood glucose and impair glycemic control in patients with diabetes. This may reduce the effectiveness of metformin-sitagliptin, and glucose may fall again when the phenothiazine is stopped.
How serious is the interaction between Metformin-sitagliptin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when prochlorperazine is started, changed or stopped, and adjust antidiabetic therapy if needed. Short antiemetic courses rarely need intervention.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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