Drug interactions
Metformin-sitagliptin + Tepotinib
Severity: Minor
Metformin-sitagliptin and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to sitagliptin, a P-gp substrate. Because sitagliptin has a wide safety margin, clinically significant toxicity is unlikely.
What this interaction means in plain words
Metformin-sitagliptin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-gp efflux, increasing sitagliptin absorption.
What to do
No routine dose adjustment is needed; monitor glucose control and for sitagliptin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Metformin-sitagliptin with Tepotinib?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may increase exposure to sitagliptin, a P-gp substrate. Because sitagliptin has a wide safety margin, clinically significant toxicity is unlikely.
How serious is the interaction between Metformin-sitagliptin and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor glucose control and for sitagliptin adverse effects.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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