Drug interactions
Metformin-sitagliptin + Vilazodone
Severity: Minor
Metformin-sitagliptin and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants may alter glucose regulation, and hypoglycemia has been reported with SSRIs in diabetic patients. Evidence for vilazodone specifically is limited.
What this interaction means in plain words
Metformin-sitagliptin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Serotonergic effects may influence insulin sensitivity and glucose counterregulation; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping vilazodone and adjust antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Vilazodone?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonergic antidepressants may alter glucose regulation, and hypoglycemia has been reported with SSRIs in diabetic patients. Evidence for vilazodone specifically is limited.
How serious is the interaction between Metformin-sitagliptin and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping vilazodone and adjust antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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