Drug interactions
Methadone + Modafinil
Severity: Minor
Methadone and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak CYP3A4 inducer and may lower methadone exposure, risking reduced effect or withdrawal. Clinical evidence is limited.
What this interaction means in plain words
Methadone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methadone belongs to Musculoskeletal; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil may weakly induce CYP3A4, increasing methadone metabolism.
What to do
Monitor for withdrawal symptoms or loss of analgesia after modafinil is started, and adjust the methadone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Methadone with Modafinil?
MediHelp rates the interaction as minor. Methadone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a weak CYP3A4 inducer and may lower methadone exposure, risking reduced effect or withdrawal. Clinical evidence is limited.
How serious is the interaction between Methadone and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or loss of analgesia after modafinil is started, and adjust the methadone dose if needed.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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