Drug interactions
methadone + ondansetron
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive QT prolongation → torsades risk.
Mechanism of action
IKr blockade additive.
Clinical management
Avoid or monitor ECG.
Drug reference
References
Frequently asked questions
Can I take methadone with ondansetron?
The interaction is rated: Major. Additive QT prolongation → torsades risk.
How serious is the interaction between methadone and ondansetron?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between methadone and ondansetron managed?
Avoid or monitor ECG.
Why do methadone and ondansetron interact?
IKr blockade additive.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.