Drug interactions
Methadone + Ozanimod
Severity: Moderate
Methadone and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites weakly inhibit MAO-B, and methadone has serotonergic activity, so serotonin syndrome or blood pressure changes are theoretically possible. Clinical evidence is limited.
What this interaction means in plain words
Methadone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by ozanimod metabolites combined with serotonergic effects of methadone.
What to do
Monitor for signs of serotonin syndrome and blood pressure changes when starting or adjusting either drug. Consider an alternative if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Methadone with Ozanimod?
MediHelp rates the interaction as moderate. Methadone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolites weakly inhibit MAO-B, and methadone has serotonergic activity, so serotonin syndrome or blood pressure changes are theoretically possible. Clinical evidence is limited.
How serious is the interaction between Methadone and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and blood pressure changes when starting or adjusting either drug. Consider an alternative if symptoms appear.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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