Drug interactions
Methadone + Panobinostat
Severity: Major
Methadone and Panobinostat: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and methadone has the same effect, so combined use raises the risk of torsades de pointes. Labeling advises against use with QT-prolonging drugs.
What this interaction means in plain words
Methadone and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methadone belongs to Musculoskeletal; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid the combination; use an alternative analgesic or opioid-substitution approach if feasible. If unavoidable, monitor ECG frequently and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Methadone with Panobinostat?
MediHelp rates the interaction as major. Methadone and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and methadone has the same effect, so combined use raises the risk of torsades de pointes. Labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Methadone and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative analgesic or opioid-substitution approach if feasible. If unavoidable, monitor ECG frequently and keep potassium and magnesium in the normal range.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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