Drug interactions
Methadone + Stiripentol
Severity: Moderate
Methadone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes, including CYP2C19 and CYP3A4, and may also induce CYP3A4, so its effect on methadone exposure is unpredictable. Methadone levels could rise, causing sedation and QT prolongation, or fall, causing withdrawal.
What this interaction means in plain words
Methadone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP enzymes involved in methadone metabolism.
What to do
Monitor for both opioid toxicity and withdrawal after starting or stopping stiripentol, and titrate methadone to response. Check ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Methadone with Stiripentol?
MediHelp rates the interaction as moderate. Methadone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes, including CYP2C19 and CYP3A4, and may also induce CYP3A4, so its effect on methadone exposure is unpredictable. Methadone levels could rise, causing sedation and QT prolongation, or fall, causing withdrawal.
How serious is the interaction between Methadone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both opioid toxicity and withdrawal after starting or stopping stiripentol, and titrate methadone to response. Check ECG if other QT risk factors are present.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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