Drug interactions
Methamphetamine + Morphine
Severity: Moderate
Methamphetamine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is a stimulant and may mask morphine-induced sedation without reducing respiratory depression. Both can affect cardiovascular function, and the stimulant may wear off before the opioid, which exposes sedation later.
What this interaction means in plain words
Methamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic CNS effects; stimulant effects do not reliably offset opioid respiratory depression.
What to do
Monitor respiratory rate, heart rate and blood pressure, and do not rely on alertness to judge the adequacy of opioid dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Morphine?
MediHelp rates the interaction as moderate. Methamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is a stimulant and may mask morphine-induced sedation without reducing respiratory depression. Both can affect cardiovascular function, and the stimulant may wear off before the opioid, which exposes sedation later.
How serious is the interaction between Methamphetamine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, heart rate and blood pressure, and do not rely on alertness to judge the adequacy of opioid dosing.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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