Drug interactions
Methamphetamine + Nilotinib
Severity: Moderate
Methamphetamine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly cleared by CYP2D6, and nilotinib can inhibit this enzyme, which may raise methamphetamine exposure. Nilotinib also prolongs the QT interval, and stimulant-related tachycardia and arrhythmia risk adds to the cardiac concern.
What this interaction means in plain words
Methamphetamine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibition of CYP2D6 may reduce methamphetamine metabolism, combined with additive cardiac effects.
What to do
Monitor heart rate, blood pressure and ECG (QTc) and keep electrolytes normal. Watch for stimulant toxicity and consider a lower methamphetamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Methamphetamine with Nilotinib?
MediHelp rates the interaction as moderate. Methamphetamine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is partly cleared by CYP2D6, and nilotinib can inhibit this enzyme, which may raise methamphetamine exposure. Nilotinib also prolongs the QT interval, and stimulant-related tachycardia and arrhythmia risk adds to the cardiac concern.
How serious is the interaction between Methamphetamine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG (QTc) and keep electrolytes normal. Watch for stimulant toxicity and consider a lower methamphetamine dose.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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