Drug interactions
Methamphetamine + Oxazepam
Severity: Moderate
Methamphetamine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is a stimulant and may partly mask the sedation from oxazepam, while the benzodiazepine may blunt anxiety and agitation. The opposing effects can lead patients to underestimate impairment, and the combination has no established therapeutic benefit.
What this interaction means in plain words
Methamphetamine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects of CNS stimulation from sympathomimetic release and CNS depression from GABA-A potentiation.
What to do
Monitor heart rate, blood pressure, and the level of alertness and anxiety. Do not rely on the stimulant to offset benzodiazepine sedation, and warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Oxazepam?
MediHelp rates the interaction as moderate. Methamphetamine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is a stimulant and may partly mask the sedation from oxazepam, while the benzodiazepine may blunt anxiety and agitation. The opposing effects can lead patients to underestimate impairment, and the combination has no established therapeutic benefit.
How serious is the interaction between Methamphetamine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, and the level of alertness and anxiety. Do not rely on the stimulant to offset benzodiazepine sedation, and warn about driving.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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