Drug interactions
Methamphetamine + Paroxetine
Severity: Moderate
Methamphetamine and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolized by CYP2D6, so paroxetine may increase its exposure. The two also have pharmacodynamic overlap that can contribute to serotonergic and sympathomimetic toxicity.
What this interaction means in plain words
Methamphetamine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by paroxetine reducing methamphetamine clearance, with additive serotonergic and sympathomimetic effects.
What to do
Start methamphetamine at the lowest dose and titrate slowly. Monitor blood pressure, heart rate, and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Paroxetine?
MediHelp rates the interaction as moderate. Methamphetamine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is partly metabolized by CYP2D6, so paroxetine may increase its exposure. The two also have pharmacodynamic overlap that can contribute to serotonergic and sympathomimetic toxicity.
How serious is the interaction between Methamphetamine and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start methamphetamine at the lowest dose and titrate slowly. Monitor blood pressure, heart rate, and signs of serotonin toxicity.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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