Drug interactions
Methamphetamine + Selegiline
Severity: Contraindicated
Methamphetamine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline inhibits MAO-B and at higher exposure MAO-A, impairing breakdown of methamphetamine-released monoamines. Hypertensive crisis and serotonin syndrome may result. Use is contraindicated.
What this interaction means in plain words
Methamphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates methamphetamine-induced monoamine release.
What to do
Do not combine; allow 14 days after selegiline before methamphetamine. Use a non-stimulant alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Methamphetamine with Selegiline?
MediHelp rates the interaction as contraindicated. Methamphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and at higher exposure MAO-A, impairing breakdown of methamphetamine-released monoamines. Hypertensive crisis and serotonin syndrome may result. Use is contraindicated.
How serious is the interaction between Methamphetamine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow 14 days after selegiline before methamphetamine. Use a non-stimulant alternative.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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