Drug interactions
Methamphetamine + Primidone
Severity: Moderate
Methamphetamine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is metabolized to phenobarbital, is sedating and anticonvulsant, while methamphetamine is a stimulant that can lower the seizure threshold. Their effects on arousal oppose each other, and seizure control may be compromised.
What this interaction means in plain words
Methamphetamine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic central nervous system effects; stimulant-related lowering of seizure threshold.
What to do
Monitor seizure frequency and alertness when methamphetamine is used with primidone. Do not use methamphetamine to counter sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Methamphetamine with Primidone?
MediHelp rates the interaction as moderate. Methamphetamine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, which is metabolized to phenobarbital, is sedating and anticonvulsant, while methamphetamine is a stimulant that can lower the seizure threshold. Their effects on arousal oppose each other, and seizure control may be compromised.
How serious is the interaction between Methamphetamine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and alertness when methamphetamine is used with primidone. Do not use methamphetamine to counter sedation.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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