Drug interactions
Methamphetamine + Promethazine
Severity: Moderate
Methamphetamine and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is sedating while methamphetamine is a strong stimulant, so they may blunt each other's effects. Phenothiazines can also reduce amphetamine effects, and both drugs may affect heart rate and rhythm.
What this interaction means in plain words
Methamphetamine and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Opposing CNS effects with dopamine receptor blockade by promethazine and additive cardiovascular effects; not fully characterized.
What to do
Monitor heart rate, blood pressure and therapeutic response. Avoid combining if the patient has cardiac arrhythmia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methamphetamine and Promethazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Promethazine?
MediHelp rates the interaction as moderate. Methamphetamine and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine is sedating while methamphetamine is a strong stimulant, so they may blunt each other's effects. Phenothiazines can also reduce amphetamine effects, and both drugs may affect heart rate and rhythm.
How serious is the interaction between Methamphetamine and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and therapeutic response. Avoid combining if the patient has cardiac arrhythmia risk factors.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
