Drug interactions
Methocarbamol + Midazolam
Severity: Major
Methocarbamol and Midazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol can add to the sedative and respiratory depressant effects of midazolam. This matters most with parenteral midazolam or in procedural settings, where oversedation and hypoventilation can occur.
What this interaction means in plain words
Methocarbamol and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methocarbamol belongs to Musculoskeletal; Midazolam belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression via pharmacodynamic synergism.
What to do
Use the lowest effective midazolam dose and titrate carefully, with continuous monitoring of respiratory rate and oxygen saturation. Avoid driving or hazardous activities after oral use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methocarbamol
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Methocarbamol with Midazolam?
MediHelp rates the interaction as major. Methocarbamol and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methocarbamol can add to the sedative and respiratory depressant effects of midazolam. This matters most with parenteral midazolam or in procedural settings, where oversedation and hypoventilation can occur.
How serious is the interaction between Methocarbamol and Midazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and titrate carefully, with continuous monitoring of respiratory rate and oxygen saturation. Avoid driving or hazardous activities after oral use.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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