Drug interactions
Methocarbamol + Papaverine
Severity: Minor
Methocarbamol and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine can occasionally cause drowsiness and dizziness, so an additive sedative effect with methocarbamol is possible but is not well documented. The clinical significance is likely small.
What this interaction means in plain words
Methocarbamol and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methocarbamol belongs to Musculoskeletal; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive sedation; the mechanism is not firmly established.
What to do
No routine change is needed. Advise patients to watch for drowsiness and to avoid driving if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methocarbamol and Papaverine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methocarbamol
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Methocarbamol with Papaverine?
MediHelp rates the interaction as minor. Methocarbamol and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine can occasionally cause drowsiness and dizziness, so an additive sedative effect with methocarbamol is possible but is not well documented. The clinical significance is likely small.
How serious is the interaction between Methocarbamol and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to watch for drowsiness and to avoid driving if it occurs.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
