Drug interactions
Methocarbamol + Temazepam
Severity: Major
Methocarbamol and Temazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic, and methocarbamol adds CNS depression. This raises the risk of oversedation, impaired coordination, falls and respiratory depression.
What this interaction means in plain words
Methocarbamol and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methocarbamol belongs to Musculoskeletal; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and central muscle relaxation.
What to do
Use the lowest effective doses for the shortest time and monitor sedation, especially in older adults. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methocarbamol and Temazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Methocarbamol
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Methocarbamol with Temazepam?
MediHelp rates the interaction as major. Methocarbamol and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temazepam is a benzodiazepine hypnotic, and methocarbamol adds CNS depression. This raises the risk of oversedation, impaired coordination, falls and respiratory depression.
How serious is the interaction between Methocarbamol and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor sedation, especially in older adults. Avoid alcohol and other sedatives.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
