Drug interactions
Methohexital + Succinylcholine
Severity: Minor
Methohexital and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is alkaline and can precipitate or inactivate when mixed with acidic succinylcholine solutions. This is a physical incompatibility rather than a pharmacologic interaction.
What this interaction means in plain words
Methohexital and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methohexital belongs to Central Nervous System; Succinylcholine belongs to Musculoskeletal.
Why it happens
pH-dependent precipitation when mixed together.
What to do
Administer separately and flush the IV line between the two drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methohexital
Other interactions of Succinylcholine
Frequently asked questions
Can I take Methohexital with Succinylcholine?
MediHelp rates the interaction as minor. Methohexital and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methohexital is alkaline and can precipitate or inactivate when mixed with acidic succinylcholine solutions. This is a physical incompatibility rather than a pharmacologic interaction.
How serious is the interaction between Methohexital and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer separately and flush the IV line between the two drugs.
What other medicines interact with Methohexital?
MediHelp also lists interactions of Methohexital with, for example, Alprazolam, Amobarbital, Buprenorphine. The full list is on the Methohexital page.
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