Drug interactions
Methohexital + Tizanidine
Severity: Moderate
Methohexital and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that produces profound CNS and respiratory depression. Tizanidine adds sedation and hypotension. The combination may deepen sedation and cardiovascular depression.
What this interaction means in plain words
Methohexital and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects, with additive hypotension.
What to do
Tell the anesthesia team that the patient takes tizanidine and titrate methohexital carefully. Monitor respiration and blood pressure during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Tizanidine?
MediHelp rates the interaction as moderate. Methohexital and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that produces profound CNS and respiratory depression. Tizanidine adds sedation and hypotension. The combination may deepen sedation and cardiovascular depression.
How serious is the interaction between Methohexital and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team that the patient takes tizanidine and titrate methohexital carefully. Monitor respiration and blood pressure during and after the procedure.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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